Postdoctoral Research Associate. Funded by CRUK-OHSU.
Hui-Ling studied biological sciences at the National Sun Yat-sen University (2003-2007, Kaohsiung, Taiwan), and at the meantime carried out her undergraduate internship at the Department of Medical Education and Research at Kaohsiung Veterans General Hospital. Under the supervision of Prof. Luo-Ping Ger, she identified the association between genetic polymorphisms in metabolic enzyme and the susceptibility to oral and pharyngeal squamous cell carcinoma. Later she did her master’s thesis at the Department and Institute of Physiology at National Yang-Ming University (2007-2009, Taipei, Taiwan) studying how inflammatory factors affect the physiological and pathological conditions. In the laboratory of Prof. Yuh-Lin Wu she uncovered that cyclooxygenase-2 (COX-2)-selective inhibitor, despite effectively attenuating prostaglandin production, could instead up-regulate the expression of certain inflammatory factors through nuclear factor-kB (NF-kB) signaling pathway in human ovarian granulosa cells under chronic inflammatory condition. Meanwhile she was also involved in studying how glucosamine suppresses infection-induced inflammatory response in human bronchial epithelial cells3. Her study was then acknowledged by the 36th International Congress of Physiological Sciences in Japan where she was granted the Young Investigator Travel Grant Award. In 2010 she was awarded the PhD Graduate Student Fellowship from the Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD) at the University of Cologne in Germany. There she reveived her PhD and postdoctoral training in the laboratory of Prof. Björn Schumacher, uncovering the mechanism through which genome stability of primordial germ cells (stem cells) can be maintained through cross-talk with somatic gonad precursor cells (niche cells) when repair machinery is compromised. The novel finding was first presented in the Annual Meeting of the German Foundation for Aging Research where she was awarded the Young Investigator Award - Best Talk. In 2019 she joins Muñoz-Espín’s laboratory to study how senescence-associated secretory phenotype (SASP) factors within tumor microenvironment impact on lung cancer initiation and progression.
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
E. González-Gualda†, M. Pàez-Ribes,†, B. Lozano-Torres,†, D. Macias, J. R Wilson III, C. González-López, H-L. Ou, S. Mirón-Barroso, Z. Zhang, A. Lérida-Viso, J. F Blandez, A. Bernardos, F. Sancenón, M. Rovira, L. Fruk, M. Serrano, G. J Doherty, R. Martínez-Máñez*, D. Muñoz-Espín*.
Aging Cell. 00:e13142, 2020.
DNA damage responses and p53 in the aging process.
Ou HL, Schumacher B.
Blood, 2018, 131(5):488-495.
Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1b-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.
Ou HL, Sun D, Peng YC, Wu YL.
Innate Immun, 2016, 22(6):452-65.
DNA damage in germ cells induces immune response triggering systemic stress resistance.
Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermohlen O, Hoppe T, Schumacher B.
Nature, 2013, 501(7467):416-20.
NAT2 slow acetylation haplotypes are associated with the increased risk of betel quid-related oral and pharyngeal squamous cell carcinoma.
Hou YY*, Ou HL*, Chu ST, Wu PC, Lu PJ, Chi CC, Leung KW, Lee CY, Wu PH, Hsiao M, Ger LP.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(4):484-92.
Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells.
Wu YL, Kou YR, Ou HL, Chien HY, Chuang KH, Liu HH, Lee TS, Tsai CY, Lu ML.
Eur J Pharmacol, 2010, 635(1-3):219-26.