Estela Gonzalez-Gualda

PhD Student. Co-funded by La Caixa Foundation and CRUK Early Detection.

Estela studied Biomedical Sciences at the University of Barcelona in Spain. Throughout her BSc studies she carried out internships at the Helholtz Zentrum Munchen (Munich, Germany) as part of the Amgen Scholars Programme, the Centre for Genomic Regulation (Barcelona, Spain), the Department of Biochemistry of the University of Cambridge (Cambridge, UK) and the Cancer Therapy Group of her home university. She was also awarded several travel grants to attend national and international conferences as a presenter, including the British Conference of Undergraduate Research at the University of Nottingham. In 2014, she founded the Biomedical Students Association of the University of Barcelona, which she presided for the next three years in order to promote international exchanges and organise seminars and conferences. In 2016, she was claimed as the only winner of the IELTS Award 2016 Spain to support her MRes Cancer Biology studies at Imperial College London (London, UK). As a master's student, she worked at the Institute for Reproductive and Developmental Biology (Imperial College London) and The Francis Crick Institute, receiving the Dean’s Prize as the top student of the year. In October 2017, she joined Daniel Munoz-Espin’s lab as a PhD student funded by La Caixa Postgraduate Fellowship. Her work focuses on the role of cellular senescence at the origin of lung cancer and during chemotherapeutic treatment


  • A two-photon probe based on naphthalimide-styrene fluorophore for the in vivo tracking of cellular senescence.
    B. Lozano-Torres,  J. F. Blandez; I. Galiana, J. A Lopez-Dominguez, M. Rovira, M. Paez-Ribes, E. González-Gualda, D. Muñoz-Espín, M. Serrano, F. Sancenón, R. Martínez-Máñez.
    Analytical Chemistry10.1021/acs.analchem.0c05447, 2021.

  • A guide to assessing cellular senescence in vitro and in vivo
    E. González-Gualda†, A.G Baker†, L. Fruk*, D. Muñoz-Espín*.
    FEBS Journal, 10.1111/febs.15570, 2020.

  • Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
    E. González-Gualda†, M. Pàez-Ribes†, B. Lozano-Torres†, D. Macias,
    J. R Wilson III, C. González-López, H-L. Ou, S. Mirón-Barroso, Z. Zhang, A. Lérida-Viso, J. F Blandez, A. Bernardos, F. Sancenón, M. Rovira, L. Fruk, M. Serrano, G. J Doherty, R. Martínez-Máñez*, D. Muñoz-Espín*. 
    Aging Cell. 00:e13142, 2020.

  • Targeting senescent cells in translational medicine.
    M. Paez-Ribes†, E. Gonzalez-Gualda†, G.J. Doherty, D. Muñoz-Espin. 
     EMBO Mol Med. 11:e10234, 2019.

  • Metastatic niche labelling reveals tissue parenchyma stem cell features. 
    Ombrato L, Nolan E, Kuerlac I, Mavousian A, Bridgeman V, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH and Malanchi I.
     Nature. 572, 603–608, 2019.

  • CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer.
    H. Kardooni, E. Gonzalez-Gualda, E. Stylianakis, S. Saffaran, J. Waxman, R.M. Kypta.  Cancers, 10, 165, 2018.

  • Inexhaustible hair-cell regeneration in young and aged zebrafish. 
    F. Pinto-Teixeira, O. Viader-Llargues, E. Torres-Mejia, M. Turan, E. González-Gualda, L. Pola-Morell, and H. Lopez-Schier.  
    Biol. Open, vol. 4, no. 7, pp. 903– 909, 2015. 

Lung Cancer Early Detection Group

Department of Oncology