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Mary denholm

Clinical Research Fellow. Funded by The Evelyn Trust

Originally from Wales, Mary completed her undergraduate medical studies at the University of Oxford (Jesus College) alongside a BA in Medical Sciences (Molecular Medicine). During her time at Oxford, she was awarded an Edwin Jones Scholarship and the Geoffrey Rushworth Prize for outstanding performance in the final year project in Medicine.

Since graduating she has worked within the NHS in several locations in the UK, as well as volunteering and contributing to healthcare education initiatives in Malawi, Zambia and India. 

Mary moved to Cambridge in 2014 to continue her medical training, obtaining Membership of the Royal College of Physicians in 2015. She has remained in the East of England for her specialist training in Clinical Oncology, obtaining Fellowship of the Royal College of Radiologists (Clinical Oncology) in 2020 and serving as the Chief Resident for the Cancer Directorate at Addenbrooke’s Hospital in 2020-21. 

Alongside her clinical work Mary has maintained a strong interest in research, in areas including oncogeriatrics and lung cancer radiotherapy. She is currently the East of England regional representative for the National Oncology Trainees Collaborative for Healthcare Research (NOTCH). 

Building on her strong clinical interest in lung cancer, Mary joined the Muñoz-Espín group in October 2021 having been awarded a Cambridge Clinical Research Fellowship funded by The Evelyn Trust. Her work in the lab focuses on clinical biomarkers and pre-clinical models of therapy-induced senescence in non-small cell lung cancer and she continues as an honorary Specialist Registrar in Clinical Oncology at Addenbrooke’s Hospital. Since starting in the lab she has also been happy to join Daniel as a member of the CRUK RadNet Cambridge team, focusing particularly on the development of translationally rich clinical trials. 

Mary is looking forward to continuing her current work as a clinical PhD student at the University of Cambridge having been awarded a CRUK Cambridge Centre Clinical Research Training Fellowship to start in October 2022.

Away from the lab and the hospital Mary enjoys music, running and baking (including trying out new recipes on her fellow lab members!).

Selected publications

  • F. Slevin, S. Pan, H. Mistry, M. Denholm, D. Shor, Z. Oong, J. Price, R. Jadon, J.C. Fleming, G. Barnett, L. Dixon, R. Prestwich and D. Thomson.

A Multicentre UK Study of Outcomes for Locally Advanced Sinonasal Squamous Cell Carcinoma Treated with Adjuvant or Definitive Intensity-modulated Radiotherapy.

 Clinical Oncology 2021 Oct;33(10):e450-e461 PMID: 34147323

  • A. Punjabi, E. Barrett, A. Cheng, A. Mulla, G. Walls, D. Johnston, J. McAleese, K. Moore, J. Hicks, K. Blyth, M. Denholm, L. Magee, D. Gilligan, S. Silverman, M. Qureshi, H. Clinch, M. Hatton, L. Philipps, S. Brown, M. O’Brien, F. McDonald, C. Faivre-Finn, C. Hiley and M. Evison.

Neutrophil-lymphocyte ratio and absolute lymphocyte count as prognostic markers in patients treated with curative intent radiotherapy for NSCLC 

Clinical Oncology 2021 Apr 13;S0936-6555(21)00142-4 PMID: 33863615

  • M. Evison, E. Barrett, A. Cheng, A. Mulla, G. Walls, D. Johnston, J. McAleese, K. Moore, J. Hicks, K. Blyth, M. Denholm, L. Magee, D. Gilligan, S. Silverman, C. Hiley, M. Qureshi, H. Clinch, M. Hatton, L. Philipps, S. Brown, M. O’Brien, F. McDonald and C. Faivre-Finn.

Predicting the risk of disease recurrence and death following curative intent radiotherapy for NSCLC: the development and validation of two scoring systems from a large multicentre UK cohort.

Clinical Oncology 2021 March; 33(3): 145-154 PMID: 32978027

  • M. Denholm, P. Corrie, W Qian and J. Hampton. 

The Rockwood Geriatric Clinical Frailty Scale is a more discriminatory tool for assessing older cancer patients compared with standard oncology performance status scales

Eur J Surgical Oncol 2017 43 (11): 2236

  • J. Jankowski and M. Denholm.

Chemoprevention: can we prevent esophageal cancer?

Chapter 21 in “Esophageal Cancer and Barrett’s Esophagus”.

3rd edition (2015), Wiley-Blackwell 

Editors: P. Sharma, R. Sampliner, D. Ilson  (ISBN: 9781118655207)

  • M. Denholm and J. Jankowski

Gastro-esophageal reflux and bulimia nervosa - a review of the literature  

Dis Esophagus 2011 Feb; 24(2): 79-85 PMID; 20659142