Postdoctoral Research Associate. Funded by MRC.
Zhenguang undertook a 5-year medical training in Xiamen University, China (2004-2009). He then moved to the University of Edinburgh to pursue his PhD under the supervision of Professor Karen Chapman and Jonathan Seckl (2009-2013). His project was focused on the study of 11β-HSD1 regulation of glucocorticoid action in macrophages, using arthritis and angiogenesis models. It revealed an indispensable role of macrophage 11β-HSD1 in inflammation resolution. Continuing work of glucocorticoid signalling in his postdoc, with Professor Andrew Loudon and David Ray at the University of Manchester (2014-2018), showed that time of day variation of lung inflammatory response was independent of airway epithelial cell glucocorticoid receptor signalling. In the meantime, he also studied transcriptome level changes of Bmal1 deficiency on airway epithelial cells by time serial RNA seq in both laser micro-dissected samples and primary cells cultured in air-liquid interface. He also found that metabolic cues can reset lung clock and inflammation response. In 2018, he joined Muñoz-Espín’s laboratory to study the role of injury-induced cell plasticity on early lung cancer development.
Genome wide effect of pulmonary airway epithelial cell specific Bmal1 deletion.
Zhenguang Zhang, Louise Hunter, Gang Wu, Robert Maidstone, Yasutaka Mizoro, Ryan Vonslon, Mark Fife, Thomas Hopwood, Nicola Begle, Ben Saer, Ping Wang, Peter Cunningham, Matthew Baxter, Hannah Durrington, John F Blaikley, Tracy Hussell, Magnus Rattray, John Hogenesch, Julie Gibbs, David W Ray, Andrew SI Loudon.
FASEB (2019). DOI: 10.1096/fj.201801682R
Louise M. Ince*, Zhenguang Zhang*, Stephen Beesley, Ryan M. Vonslow, Ben R. Saer, Laura C. Matthews, Nicola Begley, Julie E. Gibbs, David W. Ray, and Andrew S. I. Loudon.
Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signalling in airway epithelial cells.
FASEB (2018). DOI: 10.1096/fj.201800026RR
REVERBa couples the circadian clock to hepatic glucocorticoid action.
Giorgio Caratti, Mudassar Iqbal, Louise Hunter, Donghwan Kim, Ping Wang, Ryan M. Vonslow, Nicola Begley, Abigail J. Tetley,Joanna L. Woodburn, Marie Pariollaud, Robert Maidstone, Ian J. Donaldson, Zhenguang Zhang, Louise M. Ince, Gareth Kitchen, Matthew Baxter,Toryn M. Poolman, Dion A. Daniels, David R. Stirling, Chad Brocker, Frank Gonzalez, Andrew S.I. Loudon, David A. Bechtold, Magnus Rattray, Laura C. Matthews, and David W. Ray.
J Clin Invest (2018).
11beta-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.
Verma, M., Kipari, T. M. J., Zhang, Z., Man, T. Y., Forster, T., Homer, N. Z. M., Seckl, J. R., Holmes, M. C., Chapman, K. E.
Brain Behav Immun. 2017 Nov 21. pii: S0889-1591(17)30516-0.
Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis.
Zhang Z, Coutinho AE, Man TY, Kipari TM, Hadoke PW, Salter DM, Seckl JR, and Chapman KE.
Journal of Endocrinology, 2017 Sep; 234(3): 291–299.
11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice.
Agnes E. Coutinho , Tiina M.J. Kipari, Zhenguang Zhang, Cristina L. Esteves, Christopher D. Lucas, James S. Gilmour, Scott P. Webster, Brian R. Walker, Jeremy Hughes, John S. Savill, Jonathan R. Seckl, Adriano G. Rossi, and Karen E. Chapman.
Endocrinology, 2016 Jul; 7(157):2928–2936
Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation.
Chapman KE, Coutinho AE, Zhang Z, Kipari T, Savil JS, and Seckl JR.
J Steroid Biochem Mol Biol. 2013 Sep; 137(100): 82–92.
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
Kipari T, Hadoke PW, Iqbal J, Man TY, Miller E, Coutinho AE, Zhang Z, Sullivan KM, Mitic T, Livingstone DE, Schrecker C, Samuel K, White CI, Bouhlel MA, Chinetti-Gbaguidi G, Staels B, Andrew R, Walker BR, Savill JS, Chapman KE, Seckl JR.
FASEB J. 2013 Apr;27(4):1519-31